Is Sertraline (Zoloft) Safe for Dogs?
Why it’s a problem
Sertraline is an SSRI that raises serotonin levels in the brain, and dogs are much smaller than people, so a human dose can quickly overshoot. Overdoses have been reported to cause serotonin syndrome — agitation, tremors, racing heart, and dangerously high body temperature — and severe cases can progress to seizures.
How to keep your pet safe
Keep all prescriptions in a closed cabinet, not a pill organizer on the counter — dogs chew through bottles easily. If your dog needs behavior medication, a veterinarian can prescribe a pet-appropriate product; never share your own medicine.
Warning signs to watch for
Vomiting, drooling, lethargy, wobbliness, agitation, tremors, rapid heartbeat, panting, fever; in serious cases: muscle stiffness, seizures, collapse.
When to call the vet
Call your veterinarian or a pet poison hotline right away, and have the bottle handy so you can report the strength and how many pills may be missing. Do not induce vomiting unless a professional tells you to.
Common questions
My dog ate my Zoloft — what should I do?
Treat it as urgent and call your vet or a pet poison hotline now with your dog’s weight and the pill strength. SSRIs can cause serotonin syndrome, which can escalate quickly.
Do vets ever prescribe sertraline for dogs?
Yes, veterinarians sometimes use it for anxiety, but only at pet-specific doses with monitoring. Never share your own prescription — the strength and formulation differ.
More medications hazards for dogs
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate or touched something concerning, contact your veterinarian or a pet poison hotline right away. In the US: Pet Poison Helpline (855) 764-7661, ASPCA Animal Poison Control (888) 426-4435 (fees may apply).