Is Omeprazole (Prilosec) Safe for Dogs?
Why it’s conditional
Omeprazole has low acute toxicity, and dogs that swallow a tablet typically show few or no effects beyond mild GI upset. Vets do prescribe omeprazole for dogs with ulcers and reflux, but they control the dose and duration because long-term use affects stomach acid balance and nutrient absorption. Over-the-counter bottles are still a choking and overdose risk if a dog eats many.
How to keep your pet safe
Store Prilosec out of reach and never start or continue it for a dog without a vet’s direction. Chronic acid suppression without a diagnosis can hide underlying disease.
Warning signs to watch for
Usually mild: drooling, soft stool, or mild vomiting; a large ingestion can cause more noticeable GI upset and lethargy.
When to call the vet
Call your vet or a pet poison hotline with the number of tablets eaten. A single tablet generally needs only observation; many tablets warrant advice.
Common questions
My dog ate one Prilosec tablet — should I worry?
One omeprazole tablet usually causes little more than mild stomach upset in a dog, if anything. A quick call to your vet or a poison hotline provides reassurance based on your dog’s size.
My dog ate most of a Prilosec bottle — is that dangerous?
A large number of tablets can cause vomiting and significant GI upset, so call your vet or a poison hotline now. Bring or describe the packaging so the amount can be estimated.
Can I give omeprazole to my dog long term for reflux?
Only if a veterinarian prescribes and monitors it. Long-term acid suppression has real effects on digestion, and reflux has causes worth diagnosing.
More medications hazards for dogs
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate or touched something concerning, contact your veterinarian or a pet poison hotline right away. In the US: Pet Poison Helpline (855) 764-7661, ASPCA Animal Poison Control (888) 426-4435 (fees may apply).