Is Bupropion (Wellbutrin) Safe for Dogs?
Why it’s a problem
Bupropion lowers the seizure threshold more than other antidepressants, and dogs have shown seizures after ingesting relatively small amounts. It also drives fast heart rate, tremors, and dangerous overheating. This is one of the more dangerous human antidepressants for pets.
How to keep your pet safe
Keep Wellbutrin tightly stored and out of everyday reach, including bags and coat pockets. If your dog is anxious or compulsive, ask your vet for options with a better safety record for pets.
Warning signs to watch for
Vomiting, drooling, agitation, tremors, panting, rapid heart rate, high body temperature; serious cases: seizures, muscle rigidity, collapse.
When to call the vet
Call your veterinarian or a pet poison hotline immediately, even if only one tablet may have been eaten. Seizure risk means this exposure should not be handled at home.
Common questions
My dog ate my Wellbutrin — is one pill enough to hurt him?
It can be — bupropion has caused seizures in dogs at relatively low doses. Call your vet or a pet poison hotline right away with the strength and your dog’s weight.
Is bupropion worse than other antidepressants for dogs?
It is considered one of the riskier ones because seizures can occur at low exposures. Any suspected ingestion warrants an immediate call to your vet or a poison hotline.
More medications hazards for dogs
This page is general educational information, not a substitute for professional veterinary advice. Every pet is different — if your animal ate or touched something concerning, contact your veterinarian or a pet poison hotline right away. In the US: Pet Poison Helpline (855) 764-7661, ASPCA Animal Poison Control (888) 426-4435 (fees may apply).